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KMID : 1007320080140030238
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Journal of the Korean Society of Menopause
2008 Volume.14 No. 3 p.238 ~ p.245
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Relationship between Osteoporosis and Cardiovascular Disease in Postmenopausal Women
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The Study Group of Menopause
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Abstract
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Objectives: To evaluate the relationship between the risk factors of cardiovascular disease and osteoporosis.
Methods: A cross-sectional study was performed in 1,643 Korean menopausal women visited menopause clinic at 8 university hospital in Seoul, Korea. Bone mineral density of lumbar and femur neck was measured by dual X-ray absorptiometry. All participants were interviewed about the risk factors for cardiovascular diseases and their blood pressures were measured. And blood tests were done for lipid profiles and serum fasting glucose.
Results: The mean age of the patients was 59.8±9.1 year old. Fifteen percent (252/1,643) of the patient was diagnosed as having osteoporosis and 45.3% (754/1,643) was diagnosed as having osteopenia. The age of the patient was significantly older in osteoporosis group comparing osteopenia and normal group. Body mass index was significantly lower in osteoporosis than other groups. Serum triglyceride level was significantly higher in osteoporosis group (127.02±78.06 mg/dl) than other groups (osteopenia group: 115.44±60.14 mg/dl, normal group: 115.34±65.95 mg/dl). The family history of cardiovascular disease was related with low bone mass. After adjustment for potential confounders, women with hyperlipidemia had a 2.1-fold (95% CI, 1.2∼3.6; P=0.006) increase risk for osteoporosis compared with women with normal lipid profiles.
Conclusion: Postmenopausal women with hyperlipidemia are at an increased risk for osteoporosis and vice versa. These findings support the hypothesis that there are biological links between bone metabolism and atherosclerosis and suggest that postmenopausal women with osteoporosis should also be considered for the potential risk for cardiovascular events.
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KEYWORD
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Cardiovascular disease, Risk factors, Osteoporosis, Hyperlipidemia, Postmenopausal women
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